Genetics and Male Pattern Baldness
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Much research went into the genetic component of male exemplar baldness or androgenetic alopecia. Research indicates that susceptibility to premature male pattern baldness is largely sex linked.
Large studies in 2005 and 2007 stress the importance of the maternal line in the inheritance of male form baldness. German researchers language unit the androgen receptor gene as the cardinal prerequisite for balding. They close that a certain variant of the androgen receptor is needed for AGA to develop. In the same year the results of this study were confirmed by other researchers. This gene is recessive and a female would necessitate two X chromosomes with the defect to show typical male pattern alopecia. Seeing that androgens and their interaction with the androgen receptor are the lawsuit of AGA it seems logical that the androgen receptor gene plays an important part in its development.
Other investigation in 2007 suggests another gene on the X chromosome that lies close to the androgen receptor gene is an important gene in male pattern baldness. They found the domain Xq11-q12 on the X-chromosome to be strongly associated with AGA in males. They point at the EDA2R cistron as the cistron that is mostly associated with AGA. This finding has been replicated in at least three follow independant studies.
Other genes mired with hair loss have been found. One of them being a cistron on chromosome 3. This gene is also involved in a type of baldness associated with mental deceleration. This gene is recessionary.
Another gene that might be mired in hair loss is the P2RY5. This gene is linked to hair structure. Certain variants can lead to baldness at birth while another variant causes woolly hair.
Recent research confirmed the X linked androgen receptor as the most important cistron. With a gene on chromosome 20 being the second most immodest determinant gene. In may 2009 researchers in japan identified a gene Sox21 that appears to be responsible for hair loss in people. |
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By :
Paul Polkinghorne
Submitted
2012-02-01 22:18:31 |
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