CD31 antibody may help to develop novel cardiovascular therapies
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CD31, also known as PECAM1 (platelet endothelial cell adhesion molecule 1), encodes a type I integral membrane protein and member of the immunoglobulin receptor superfamily. The CD31 antibody is widely used as an endothelial marker.
CD31 is expressed on a number of cell types, including macrophages, lymphocytes and endothelial cells, and is specifically concentrated at endothelial junctions. CD31 antibody studies have shown PECAM1 is also expressed in a number of soft tissue, vascular and endothelial tumours; the CD31 antibody database is a useful source of endothelial markers when studying angiogenesis in connection with tumour recurrence.
CD31 is expressed on the membranes of some endothelial blood-vessel cells. Recently, cardiologist Young-sup Yoon, of Emory University, published a CD31 antibody study suggesting CD31 may be significant in developing new cardiovascular therapies.
In Yoon’s study, the CD31 antibody was used in both donated human blood and mouse bone marrow cells to detect and isolate CD31(+) endothelial cells. Using an in vivo mouse model of PVD (peripheral vascular disease), it was seen that CD31(+) cells secreted hormones which supported the growth of new vasculature, enabling continued circulation through the legs. In vitro, CD31(+) cells were shown to mimic the growth of new blood vessels by developing tubular structures.
It was suggested that harvesting CD31-positive cells had several advantages over stem cells. They can be grown quickly, and do not require large volumes of patient blood or bone marrow. It is hoped the research may pave the way for novel cardiovascular disease treatments in the future.
We at Novus Biologicals have an extensive antibody database to support vascular research, to which we recently added a new CD31 antibody.
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The Article is written by www.novusbio.com providing Antibody Catalogue and Antibody Database. Visit http://www.novusbio.com for more information on www.novusbio.com Products and Services___________________________Copyright information This article is free for reproduction but must be reproduced in its entirety, including live links and this copyright statement must be included. Visit www.novusbio.com for more services!
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By :
Gen Federico
Submitted
2011-08-29 00:36:17 |
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